Manuscript on LC-MS/MS Method for Quantifying the HIV-1 Broadly Neutralizing Antibody PGT 121.414.LS in Human Serum
December 01, 2025
The CPQA has recently published “LC-MS/MS Method for Quantifying the HIV-1 Broadly Neutralizing Antibody PGT 121.414.LS in Human Serum” in the Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.
Highlights:
- Quantitative mass spectrometry assay for antibody PGT 121.414.LS used in HIV-1 therapeutics.
- Sample matrix effects were reduced using ammonium sulfate precipitation or affinity capture.
- High specificity for determination of PGT 121.414.LS levels in serum is achieved using LC-MS/MS.
Publication: LC-MS/MS method for quantifying the HIV-1 broadly neutralizing antibody PGT 121.414.LS in human serum, Journal of Chromatography B, Volume 1266, 2025.
Authors: Connor E. Gould, Qing Ma, Raymond Cha, Kevin J. Zemaitis, Robin DiFrancesco, Gene D. Morse, Troy D. Wood
The manuscript can be accessed here.
